COMPLERA is a triple combination pill containing emtricitabine, tenofovir disoproxil fumerate and rilpivirine. COMPLERA is taken once a day at the same time and should be taken on an empty stomach before going to bed to prevent side effects. Sometimes there are mild side effects in the first few weeks of taking COMPLERA that include; mood changes/depression, disturbed sleep, general malaise, and mild stomach problems. COMPLERA is available in some countries it is available as a generic. COMPLERA is also known as EVIPLERA.