EVIPLERA is a triple combination pill containing emtricitabine, tenofovir disoproxil fumerate, and rilpivirine. EVIPLERA is taken once a day at the same time and should be taken on an empty stomach before going to bed to prevent side effects. Sometimes there are mild side effects in the first few weeks of taking EVIPLERA that include; mood changes/depression, disturbed sleep, general malaise, and mild stomach problems. EVIPLERA is available in some countries as a generic. EVIPLERA is also known as COMPLERA.